& Demaria, M
BAL fluid and intracellular GSH pathways correlate with HAEC T2-associated gene expression To determine whether these in vitro findings were reflected ex vivo, BAL fluid GSSG levels were compared to fresh HAEC expression of T2-related genes from 2 different RNA-Seq databases (SARP3 and IMSA), which were harmonized and merged as outlined in the Methods (Table 3)
This notable reduction in oxidative phosphorylation may be linked to the stressed and inflammatory microenvironment within rejection regions, which may suppress mitochondrial electron transport chain (ETC) related genes in stromal cells (34)
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Genazzani AD, Prati A, Marchini F, Petrillo T, Napolitano A, Simoncini T (2019) Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both