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The compounds were incubated in the presence of rat blood serum samples and all of the resulting incubates were analyzed by HPLC in order to determine their rate of metabolic activity

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Using in vitro cell-based assays, the researchers found that while both peptides activated the amylin and calcitonin receptors, KBP-336 was more potent and showed a bias towards the calcitonin receptor compared to cagrilintide

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Sikiric 2006)