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UK clinical guidance does not currently address the specific combination of NAD+ supplements and retatrutide, primarily because retatrutide remains unlicensed and is not part of standard NHS prescribing practice

In clinics it is used for skin brightening and antioxidant support

Even people in a trial environment who are set up for success with coaches and dieticians see that, once their weight plateaus after about a year or so, it starts to go up again very gradually despite still being on the medication

Fluid retention and edema: During treatment with glucocorticoids and diclofenac, edema and fluid retention have been observed so the formula must be used with caution in patients with a history of decompensation, hypertension or other factors predisposing to fluid retention

However, prolonged gastric retention also means delayed arrival at the intrinsic factor binding sites and the ileal absorption receptors

Important clinical note: Prescribers should counsel patients that compounded preparations are not FDA-approved, that quality can vary between pharmacies, and that the evidence base for specific compounded formulations is more limited than for FDA-approved products