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Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells

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After invasion into the host, mycobacteria induce NADPH oxidase 2 (NOX2) expression to generate superoxide radicals (O 2 ), which are then converted to more toxic hydrogen peroxide (H 2 O 2 ) by superoxide dismutase (SOD) and subsequently reduced to water and molecular oxygen by catalase [57, 58]