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In the SURMOUNT trials for obesity, gastrointestinal adverse events increased with dose: 39% at 5 mg, 46% at 10 mg, and 49% at the 15 mg dose
Summary: Low blood sugar risk with retatrutide is theoretically lower than with sulphonylureas or insulin due to its glucose-dependent mechanism, but the risk increases when retatrutide is combined with other glucose-lowering therapies
Renal function may be monitored, particularly if patients experience significant gastrointestinal adverse effects that could lead to dehydration
Although the osteocyte is generally considered as the primary sensor of mechanical load, evidence of contributions by other cell populations are present in the literature
Including more lean protein is a practical way to help meet daily nutrition needs while on compounded semaglutide
