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Clinical Dosing Data and Pen-Based Interpretation Phase 2 Obesity Trial (48 Weeks) The pivotal Phase 2 trial demonstrated: Up to ~24% mean weight reduction Strong dose-response relationship Higher doses associated with greater metabolic improvement Reference: Clinical trial registry: Phase 2 Type 2 Diabetes Study Parallel metabolic trials demonstrated: Significant HbA1c reductions Improved fasting glucose Improved post-prandial glucose control Reduction in insulin resistance markers Reference: Coskun T et al., Cell Metabolism , 2022 Dose Escalation Strategy Across studies, retatrutide was not initiated at target doses

Safety and tolerability of oral semaglutide were consistent with subcutaneous liraglutide 1.8 mg in the PIONEER 4 study [9]

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Vaughn AR, Branum A, Sivamani RK