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[1] [2] Long-term cardiovascular outcomes and the full safety profile of this mechanism in humans remain to be established in ongoing Phase 3 trials

The real question: Will either medication achieve the sustained, widespread use needed to address the global obesity epidemic

Over-interpretation of secondary outcomes may lead to spurious inferences, underscoring the need for caution when translating these findings into clinical reassurance.This aligns with emerging data linking metabolic improvements such as weight loss, insulin sensitivity, and reduced inflammation to decreased malignancy risk in high-risk populations with type 2 diabetes or obesity (Marso et al., 2016a