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This mitochondrial dysfunction shifts cellular metabolism toward aerobic glycolysis (Warburg-like effect), promoting a pro-inflammatory phenotype that, while beneficial for fungal clearance in acute infection, can exacerbate immunopathology during chronic infection ( Moreover, gliotoxin from Aspergillus fumigatus and candidalysin from Candida albicans synergistically impair mitochondrial ATP production, weakening epithelial barrier integrity and facilitating fungal invasion ( 4.3 Fungal-induced mitochondrial ROS generation and oxidative stress One of the earliest mitochondrial responses to fungal infection is the excessive generation of mtROS

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