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Moving to the ability of metformin to reduce the metastatic potential, it was demonstrated that the drug not only reduced the migration of MTC cancer cells (Klubo-Gwiezdzinska et al., 2012), but also modified the expression of several markers of the epithelial-tomesenchimal-transition (EMT) ( in vitro
The patent ultimately lapsed permanently because Novo Nordisk failed to pay the 2019 maintenance fee
Despite the inability of erythrocytes to upregulate antioxidant enzymes at the transcriptional level, its antioxidant system, relying primarily on reduced glutathione (GSH), is involved in the regulation of the redox equilibrium in blood
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The saikosaponin family exerts its antidepressant effects through various pathways: promoting ubiquitination of NLRP3 inflammasome, inhibiting NF-B pathway, upregulating the expression of anti-ferroptotic proteins (GPX4, Nrf2, and SLC7A11) and attenuating lipid peroxidation
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