PYX-201, a stroma-targeting ADC composed of an anti-EDB+FN antibody conjugated to Auristatin0101, demonstrates strong anti-tumor efficacy across multiple human cancer indications in pre-clinical PDX tumor models
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Among chemical strategies, norepinephrine and N -methyldopamine can be used to promote exosome secretion from MSCs without changing their ability to induce angiogenesis, polarize macrophages to an anti-inflammatory phenotype, or downregulate collagen expression [226]
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