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Genitourinary Common (1% to 10%): Urinary tract infection, urolithiasis Postmarketing reports : Urolithiasis Hepatic Common (1% to 10%): Cholelithiasis, cholecystitis Uncommon (0.1% to 1%): Increased bilirubin Postmarketing reports : Cholecystitis, cholelithiasis requiring cholecystectomy Hypersensitivity Uncommon (0.1% to 1%): Hypersensitivity Rare (0.01% to 0.1%): Anaphylactic reaction Frequency not reported : Allergic reactions Postmarketing reports : Hypersensitivity, anaphylaxis Hypersensitivity included related adverse events such as rash and urticaria

Because peptide therapy may affect different body systems, medical evaluation and ongoing provider guidance are important before and during treatment

The EXAMINE and SAVOR-TIMI 53 studies were excluded from sensitivity analyses because DPP-IV inhibitor drugs did not show CV benefit in their individual trials

Primary Handling Editors: Rosie Bunton-Stasyshyn & Mengtan Xing

A number of clinical trials assessed the effects of flumazenil in patients with HE

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