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Gastrointestinal side effects are the most frequently reported adverse reactions with GLP-1 receptor agonists, particularly during the initial weeks of treatment or following dose escalation

46 Thyroid hormone receptor agonist: resmetirom (MGL-3196) Thyroid hormone receptor agonist, highly expressed in hepatocytes, regulates many metabolic pathways, including the reduction of triglyceride and cholesterol levels, improvement of insulin sensitivity, promotion of liver regeneration, and reduction of cell apoptosis

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Specific dietary adjustments can significantly reduce gas production: Limit carbonated beverages , which introduce additional gas into the digestive system Reduce intake of gas-producing foods such as beans, lentils, cruciferous vegetables (broccoli, cauliflower, cabbage), onions, and certain fruits Avoid fatty and fried foods , which further delay gastric emptying and may exacerbate symptoms Minimize artificial sweeteners (sorbitol, mannitol, xylitol), which can ferment in the gut Reduce dairy products if lactose intolerance is suspected Limit high-fiber foods temporarily during periods of significant symptoms Eating behaviors also play a crucial role