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This apparently minor modification produces a substantial functional change: the N-terminal tripeptide is the primary binding domain through which IGF-1 interacts with IGFBP-3 and IGFBP-1, the two most abundant binding proteins in circulation
However, its action is shorter and often requires frequent dosing
M., Nygard, O
Over time, this helps reduce the appearance of pigmentation and contributes to a brighter, more refreshed complexion
One intriguingbut speculativepossibility is that GSSG might paradoxically protect the ER by exacerbating protein misfolding, if doing so renders misfolded client proteins more readily recognized and either refolded or cleared rather than futilely engaged with the ER quality control machinery
(GSH)
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