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These medications are typically prescribed when lifestyle modifications and oral diabetes medications have not achieved adequate glycaemic control, or as part of a comprehensive weight management programme for eligible patients
Educating patients on why it is important to adhere to the schedule and report issues aids them in making it through the initiation phase safely
Retatrutides 24.2% weight loss compares to the 25-30% typically seen with gastric sleeve surgery, offering similar results without surgical risks or anatomical changes
However, when compared to insulin, GLP-1 RAs provided protection against advanced-stage DR
Half-life is the amount of time it takes for the drugs initial concentration in the body to decrease by half
The most frequently reported side effects for both include: Nausea (most common, especially during dose escalation) Diarrhea Constipation Vomiting Decreased appetite (technically the intended effect) Abdominal discomfort For tirzepatide, these side effects are well-characterized from multiple large Phase 3 trials and extensive real-world use
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