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In the 28-week, phase three randomized control trial (RCT) DURATION-8, dual therapy with an SGLT2 inhibitor (dapagliflozin) and a GLP-1RA (once-weekly exenatide) was shown to reduce HbA1c by 0.4% more than either agent alone, in patients with a starting HbA1c of between 8-12% 50 , illustrating that the glycemic response to dual therapy is less than additive 50
Common examples include semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro, Zepbound)
T., Hawn, M
Shed been on Mounjaro (tirzepatide) for diabetes and was doing great with weight loss as a side effect
The tripeptide is broken down by digestive enzymes in the gut before significant amounts can reach the bloodstream intact
Why Symptoms May Appear During Rapid GLP-1 Weight Loss Several changes can occur at the same time
