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The FDA has issued warnings to companies that have illegally sold drugs labeled for research purposes or not for human consumption. Some of these products have been sold directly to consumers for human use, even though they were specifically labeled not to be used in humans

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The FDA cited three concerns: potential immunogenicity (the peptide could trigger immune reactions), manufacturing impurity risks (synthetic peptides can contain truncated sequences and other contaminants), and a lack of human safety data sufficient to evaluate risk

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The unimolecular approach is simpler but less flexible