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Differential contribution of hepatitis C virus NS5A and core proteins to the induction of oxidative and nitrosative stress in human hepatocyte-derived cells
10.1038/sj.jid.5700253 82 OkabeS.AmagaseK
10.1111/j.1462-5822.2004.00428.x Cell
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The rest of the structure is identical to the 177-191 amino acid sequence of hGH, including the disulfide bridge between the two cysteine amino acids (Cys182 and Cys189), which in the case of AOD-9604 are at the 7th and 14th positions [7]
The peptide also promotes polarization of macrophages from pro-inflammatory M1 phenotypes toward tissue-repairing M2 phenotypes, with treated macrophages showing 70% increased phagocytic activity for clearing inflammatory debris and 3-fold higher production of VEGF compared to untreated controls
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