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One thing is that, in trials, some of these new medications are increasing the amount of weight loss, but that means higher reward, higher risk, with more side effects, says John Morton, MD, MPH, chief of Yale Medicine Bariatric and Minimally Invasive Surgery and a board-certified obesity medicine specialist
They frequently caused severe hunger (due to non-selective ghrelin agonism) and elevated cortisol and prolactin levels
Moreover, small-molecule GLP-1RAs offer a solution to the bioavailability limitations faced by oral peptide-based agents, which often depend on absorption enhancers (e.g., SNAC) and strict fasting protocols [74]
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1200 kcal/nap, frfiaknl kb
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