Designed to Be Taken With Meals
Yet medicine rarely gives benefit without trade-offs
Mechanisms of L-cell GLP-1 secretion Physiologically, L-cells, which are most common in the distal parts of the intestines [15], are stimulated to secrete all their secretory products (GLP-1, GLP-2, gut-derived glucagon [also called glicentin], peptide tyrosine tyrosine, oxyntomodulin) in response to nutrient ingestion [16, 17]
Key factors like the peptides half-life, distribution patterns, and clearance rates should be considered when planning the dosing regimen
GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors
Learn more on ClinicalTrials.gov: CT-996 is a once daily oral small molecule agonist of the GLP-1 receptor being developed for the treatment of obesity and type 2 diabetes
