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Inflammatory mediators such as histamine, proteolytic enzymes, glycolytic enzymes, and heparin, as well as de novo synthesized prostaglandin D2 (PGD2), leukotriene C4 (LTC4), adenosine, and ROS are released from mast cell granules (34), and they directly induce oxidative stress ( Figure 1 )

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"Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside." Int J Mol Sci

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8-OHdG elevation may be due to both increased load of ROS and decreased expression of OGG1, the base excision repair gene that excises and repairs single base mutations, which in fact was found in endometriosis patients (105)

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In addition, those who were more sedentary had worse eGFRs and were more likely to die from cardiovascular disease or any cause

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