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A quick recap: how GLP-1 medications work GLP-1 receptor agonists mimic a natural hormone called glucagon-like peptide-1, which is released in the gut after eating

Variants in GIPR, FTO, and MC4R genes may provide context, but clinical response depends on multiple factors including diet, lifestyle, dosing, and individual metabolism

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This doesnt necessarily mean that HRT boosts semaglutides efficacy, the study authors proposed, but rather that not receiving HRT may weaken the post-menopausal bodys response to semaglutide