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The results revealed a significant four-fold increase in bone formation in rats that received both corticosteroids and ipamorelin compared to those who solely received the corticosteroid drug [4]

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They also demonstrated that dietary supplementation of apoE / mice with choline, TMAO or betaine drives atherosclerosis by upregulating the scavenger receptors CD36 and SR-A1 on macrophages, leading to increased cholesterol accumulation and formation of foam cells ( The apoE / mice fed with dietary TMAO for 8 weeks were found to have increased atheromatous plaques in the aorta and elevated serum lipids compared to the control group, which was demonstrated to be due to the inhibition of hepatic bile acid synthesis in mice possibly by downregulating Cyp7a1 (i.e., cholesterol 7-hydroxylase, the key regulatory enzyme of hepatic bile acid biosynthesis) (Shah, 2003)

Complexity and simplification in the development of nanomedicines

Nov 2006;36(6):1345-59, viii

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