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Freitas, Renata Germano Borges de Oliveira Nascimento, et al
A mitochondrial-targeting H 2 O 2 -responsive theranostic prodrug (PNPS) was developed by conjugating 5-deoxy-5-fluorouridine (5-DFUR) to NIR photosensitizer (NPS) through a bisboronate group (Fig
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In OA cartilage tissues and IL-1stimulated chondrocyte models, iron accumulation, elevated levels of lipid peroxidation byproducts such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), and downregulation of the antioxidant enzyme GPX4 have been widely reported (5153)
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