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ECs contain two types of K + channels: Ca 2+ -activated K + channels (K Ca ) and inward-rectifier K + channels from the Kir2 family (K IR )

Cancer and IR Numerous recent epidemiological studies have suggested that IR increases the risks for different cancers including colon, liver, pancreas, breast, endometrium, thyroid and gastric cancer

Deferasirox-dependent iron chelation enhances mitochondrial dysfunction and restores p53 signaling by stabilization of p53 family members in leukemic cells