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Repeated intracerebroventricular administration of glucagon-like peptide-1-736 amide or exendin939 alters body weight in the rat
Nausea is by far the most commonly reported symptom and tends to appear early, especially during dose increases. Vomiting, diarrhea, and constipation can also occur, though their frequency depends on the specific medication and dose
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Accordingly, large clinical trials on the safety and efficacy of these earlier GLP-1 RAs are available
Understanding why GLP-1 therapy affects heart rate requires examining both the direct pharmacological actions of these medications and their indirect metabolic and hemodynamic effects on the cardiovascular system
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