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GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety ( 2 GLP-1R GLP-1R is a G protein-coupled receptor (Wu et al., 2020) (Figure 1A)

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Overall, GLP-1 may improve cognitive function by promoting neuronal stem cell proliferation and differentiation

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Diabetes & Metabolism Journal 49 (3)

These coordinated effects accelerate cell division rates and support tissue development and regeneration