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Phase I/II study of DZD6008, a 4th-generation EGFR TKI with full BBB penetration, in EGFR-mutant NSCLC
Multiple randomized controlled trials and meta-analyses in patients with type 2 diabetes and obesity demonstrate that GLP-1RA therapy either preserves or modestly increases bone mineral density (BMD) at key skeletal sites lumbar spine and hip, GLP-1RAs also favorably modulate bone turnover markers, increasing bone formation markers (P1NP, osteocalcin, bone-specific alkaline phosphatase) and reducing bone resorption markers (-CTX), suggesting a net positive or neutral effect on bone remodeling
However, the act of doing so has a downside: it involves the continuous, insidious production of toxic molecules called free radicals or reactive oxygen species (ROS)
In this regard, most studies look at berberines effects on nonalcoholic fatty liver disease, but inflammation is also a critical part of conditions like heart disease and diabetes.12 17 Notably, a 2020 meta-analysis found significant reductions in CRP (C-reactive protein, a major marker of inflammation) in patients taking berberine.18 A 2024 review of randomized controlled trials corroborated the findings of the 2020 meta-analysis.53 For diabetes care One of the few things we can almost conclusively say berberine supports is diabetic care
A peer-reviewed study in the Journal of Clinical Endocrinology and Metabolism confirming that CJC-1295 produces sustained, dose-dependent increases in GH and IGF-1 levels with a favorable safety profile in healthy adults
(532) analyzed documents from the National Diet and Nutrition Survey Rolling Programme (NDNS RP) 20082014 to evaluate polyphenol consumption among the UK population
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