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2026-02-19 QP (Qualified Person) ID: QP-001 QP: NMPA-QP-SH-864 2026-02-19 DOCUMENT ID: QC2026-VL0109-4143 | PRINTED: 2026-08-04 | : KNV3Y4NZ-QCWF

An additional consideration is the methodological quality of the included trials

At the biochemical level, iron-mediated oxidative stress is largely driven by the Fenton reaction, which converts hydrogen peroxide into highly reactive hydroxyl radicals capable of inducing widespread biomolecular damage

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While familial ALS is typically caused by hereditary genetic mutations, the cause of sporadic ALS (comprising 90% of all cases) is not completely understood

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