It is important to let your clients know about this program and instruct them to apply by filling out the application with their family doctor
It is not for human use, injection, consumption, veterinary applications or any medical purposes
Updated July 2026
Choose methylcobalamin if: You have confirmed MTHFR mutations Elevated homocysteine levels Neurological or mood symptoms You tolerate methylated supplements well Choose hydroxocobalamin if: Sensitive to methyl-B12 (anxiety, insomnia) Histamine intolerance or MCAS Need gentle, balanced B12 support Want detoxification benefits Choose adenosylcobalamin if: Chronic fatigue is your primary concern Mitochondrial dysfunction Want to combine with methyl-B12 for comprehensive support Consider combination formulas: Many practitioners recommend combining forms: Methyl-B12 + Adeno-B12 (methylation + energy) Hydroxy-B12 + Adeno-B12 (gentle + energy) All three forms for comprehensive support The bottom line: For MTHFR mutations, methylcobalamin is typically most effective for supporting methylation and lowering homocysteine
It competes with nicotinamide (NAM) for the active binding site of NNMT, preventing the enzyme from catalyzing the transfer of a methyl group from SAM to NAM
Its found in lots of common foods, like: Advertisement If youre found to have low B12, your healthcare provider may first try over-the-counter supplementation like a dissolvable B12 capsule or tablet or a B12 nasal spray