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The researchers accessed the damaged knees using arthroscopic subchondral drilling (into the layer of bone just beneath the cartilage), a long-standing method of stimulating the bone marrow

Patients should also be aware that certain medicationssuch as proton pump inhibitors (PPIs) and metformincan interfere with B12 absorption, though this is less relevant once on injection therapy

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No consistent serious adverse events have emerged in limited case series

Collagen and glycosaminoglycans play a key role in skin hydration, elasticity, and structural strength