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This causes: Increased membrane permeability Tubular cell injury and necrosis GFR Result: Acute tubular necrosislike picture 2 Renal vasoconstriction (hemodynamic effect) Amphotericin B causes afferent arteriolar vasoconstriction

TRL, triglyceride-rich lipoprotein

Moreover, glutamine-dependent PDAC is sensitive to the SLC7A11 inhibitor erastin, which induces ferroptosis 62,63

The rapid transit bypasses the normal gastric reservoir function, creating a 'nutrient bolus' effect that triggers excessive incretin secretion

You need a minimum of 1.2 grams of protein per kilogram of body weight per day during active weight loss, and ideally closer to 0.6 to 0.75 grams per pound of your goal body weight

At the high end for strong responders (30%), thats approximately 51 lbs