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Importantly, we also demonstrate that GLP-1 and its derivatives directly antagonize TRPV1 channels in a mode-selective manner that can offer pain relief without the adverse thermoregulatory side effects commonly associated with current TRPV1 inhibitors

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The addition of glucagon-receptor activity to the dual-incretin mechanism (already represented by compounds such as tirzepatide) is hypothesized in the literature to extend the molecule's effects on hepatic lipid handling and energy expenditure beyond what is observed with GLP-1/GIP co-agonism alone

The use of GLP-1 receptor agonists is frequently associated with gastrointestinal adverse effects, particularly nausea, vomiting, diarrhea or constipation

they answered directly and satisfactorily, and we bid each other a good day