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These results provide experimental support for indirectly correcting downstream PCD imbalance through metabolic/autophagy axis. However, this strategy is also not cost-free: mTOR inhibitors like rapamycin carry risks of immunosuppression and metabolic disorders, and long-term use may further weaken the anti-infection ability of COPD patients

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Semaglutide improves postprandial glucose and lipid metabolism, and delays first-hour gastric emptying in subjects with obesity