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8 July 2018

While robust clinical trial data specific to these combinations continues to emerge, the physiological rationale and supporting evidence from component studies provide a sound basis for clinical application in appropriately selected patients

Composed of endothelial cells connected by tight and adherens junctions, along with supporting cells such as enteric glial cells, pericytes, and fibroblasts, this barrier prevents the translocation of bacteria, toxins, and inflammatory mediators into systemic circulation (Spadoni et al., 2015)

We furthermore thank Luise Krauth-Siegel for helpful discussions and Tobias Dick and Bruce Morgan for reading an initial version of the manuscript and suggestions

(PubMed) Purpura M, Jager R, Godavarthi A, Bhaskarachar D, Tinsley GM

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