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The GI problems are most likely associated with synthetic GLPs, Daniell says, because such complaints were not frequent with natural GLP-1RAs like lixisenatide or exenatide for the past 45 years. Finally, reducing the steps in the production of GLP-1 receptor agonists also means that the overall cost should be lower
Other drugs like octreotide (somatostatin agonist) and bromocriptine (dopamine agonist) can be used to block GH secretion because both somatostatin and dopamine negatively inhibit GHRH-mediated GH release from the anterior pituitary
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