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Notwithstanding this limitation, the prescription of GLP-1 RAs has increased approximately 700% in the US during the past 4 y, and approximately 12% of US adults have been prescribed GLP-1 RAs, with 6% of the population prescribed semaglutide.Reference Mahase 49 , Reference Harris 50 In addition, as stated earlier, GLP-1 RAs are indicated and/or prescribed off-label for many conditions known to differentially affect persons living with depressive and bipolar disorders.Reference McIntyre, Kwan, Rosenblat, Teopiz and Mansur 36 Consequently, it can be assumed that a percentage (albeit unknown percentage) of persons prescribed lithium may also have been co-prescribed a GLP-1 RA

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doi: 10.3390/ijms20040952 6 HanahanDWeinbergRA

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