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Typically, if bedtime is 9:30 pm, melatonin is given around 9:00 pm as part of a wind-down routine (dim lights, no screens, etc., to work with melatonin, not against it)

Growth Hormone & IGF Research, 16 (2), 132-142

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit brain in 1977, named for its ability to promote slow-wave (delta) sleep

Copper peptides are generally safe for most people when used topically, as they don't enter the body to produce systemic effects, but copper peptides might not be appropriate for people with a known allergy or sensitivity to copper

144 In addition, the lack of assurance that there is an effective concentration of glutathione in the lung is another major reason for not achieving the desired therapeutic effect

Timing can also play a role