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SIRT1 also indirectly modulates key molecules in the insulin signaling pathway, such as insulin receptor substrate 2 (IRS2) by influencing members of the forkhead transcription factors (FOXO) family, ultimately alleviating insulin resistance [108,109,110]

G., & Coombes, J

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We further predicted that the identified neurometabolite alterations would be associated with the severity of ASD symptomatology

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