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Study Duration: 50 days

Over-activation and/or chronic activation of microglia cause excessive and uncontrolled neuroinflammatory responses, leading to a self-perpetuating vicious cycle of neurodegeneration (14)

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510 For instance, the activation of NOP2/Sun RNA methyltransferase 2 (NSUN2) maintains global 5-methylcytosine (m5C) RNA methylation, including that of TREX2, stabilizing it and thereby restricting cytosolic dsDNA accumulation and cGAS/STING activation

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