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Bax oligomerization is associated with the formation of openings in the OMM to allow the release of cytochrome c and other IMS proteins into the cytosol, and hence Bax oligomerization is considered a critical regulatory point in cell death (Youle and Strasser, 2008)
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In fact, LC worsened CIPN severity over time
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In cell-based assays, ester-linked diacylglycerols (DAGs) activate PKC- and promote cellular proliferation
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