To confirm -cell identity loss in islets from patients with T2D, we performed immunofluorescence staining of pancreatic sections from patients with T2D and ND individuals using antibodies against INS and GCG
For many research teams, the holy grail isnt an injectable at allits a pill
Back Althage, MC, Ford, EL, Wang, S, et al (27 June 2008) 'Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet', Journal of Biological Chemistry , 283/26, 18365-76
Topical application is the preferred route for cosmetic-adjacent skin research because it delivers the peptide directly to the target tissue while avoiding systemic exposure
While the GLP-1s affected familiar territory, they also triggered activity in the central amygdala, a region associated with desire that is deeper in the brain than scientists previously thought GLP-1s could directly reach
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