In addition, the inhibition of de novo sphingolipid biosynthesis by adipocyte-specific knockout of serine palmitoyltransferase 2 (Sptlc2), which catalyzes the first step of de novo sphingolipid synthesis, exhibited impaired adipose tissue development and a lipodystrophic phenotype, which progressed to systemic insulin resistance [99]
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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
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Bassan M, Zamostiano R, Davidson A, Pinhasov A, Giladi E, Perl O, et al
Additionally, changes in estrous cycle, recovery of ovary/uterus including increase of uterine weight, decrease of ovary weight are observed in letrozole-induced PCOS rats [80]