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The medication initially slows gastric emptying, which prolongs the feeling of fullness after meals and reduces overall caloric intake

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In the placebo arm, those with obesity showed a common imbalance of overeating: their brains reward areas lit up with the cue light, indicating high craving or wanting , but their neural response during the actual tasting was blunted, indicating lower liking

Ethics declarations Ethical Approval Ethics committee approval is not required because secondary data has been used in the study

Both suppress mesolimbic reward circuits, reducing the hedonic drive to eat

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