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In SH-SY5Y cells, the nanosystem showed superior cytoprotection against MPP+-induced cytotoxicity, increasing cell viability to 98.66% at 50 M compared to 44% viability in untreated controls

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they are the direct result of measurable, systemic metabolic dysfunction

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It acts directly on several target tissues, including skeletal muscle and bone, but several effects are mediated indirectly by circulating (liver-derived) or locally produced IGF-1