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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility
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primary endpoint in both trials) was determined using a non-compartmental method and applying the trapezoidal rule on observed concentrations and actual sampling time points
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Rosen T, Bengtsson BA 1990 Premature mortality due to cardiovascular disease in hypopituitarism
This scenario is frequently misinterpreted
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