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doi: 10.1016/j.jpsychires.2023.02.007

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[33] In contrast to peripheral administration, when administered intranasally via a nasal spray, oxytocin reliably crosses the bloodbrain barrier and exhibits psychoactive effects in humans

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Importantly, PAMPs such as LPS are already known to induce endogenous glucocorticoid release in humans [59] and mice [60]

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