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But those differences largely disappeared once the researchers tracked the same people over time, suggesting the apparent gaps reflected differences between the people taking the medications rather than changes caused by the drugs themselves

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However, it is not clear what contributed specifically to this effect on inflammation, though increasing evidence suggests that IGF-1 signaling is critical for maintaining immune cell homeostasis 44 , but the prospects of sex differences in the requirement for IGF-1 signaling in these cells is not yet known and will require further study