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Long-term bone density, cardiovascular function, and metabolic markers have shown no significant decline in extended-use populations

8 Allen J, Bradley RD

However, systemically injected labeled GLP1RAs show limited brain penetration, with the strongest labeling observed in circumventricular organs such as the AP and arcuate nucleus (ARC), suggesting that most central effects are mediated by downstream signaling from these primary GLP1RA binding sites 14

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Additionally, the expiration of patents for blockbuster GLP-1 therapeutics, such as semaglutide, is stimulating the market for generics and biosimilars

Zavorsky GS, Kubow S, Grey V, Riverin V, Lands LC