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According to Xu and Zhuang [35], oxidative cell damage also leads to an increase in the oxidation of proteins and lipids after OLZ therapy

Clinical scenarios warranting consideration of GLP-1 therapy include: Type 2 diabetes management : Per ADA 2024 Standards of Care, GLP-1 RAs may be considered as initial therapy in patients with established atherosclerotic cardiovascular disease (ASCVD), high ASCVD risk, chronic kidney disease (CKD), or heart failure, or as add-on therapy when glycemic targets aren't met Established cardiovascular disease : Several GLP-1 receptor agonists have demonstrated cardiovascular risk reduction in patients with type 2 diabetes and established ASCVD Chronic kidney disease : While SGLT2 inhibitors are generally prioritized for CKD with type 2 diabetes when eGFR allows, GLP-1 RAs may provide complementary benefits Obesity with complications : When lifestyle interventions produce insufficient weight loss in patients with obesity-related comorbidities Important safety considerations include: Contraindications : Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

The Verdict: May offer short-term appetite effects, but unlikely to provide significant weight loss when used alone

Given the fibrosis severity in this model, it is speculated that alleviation of liver fibrosis may lead to increased TG and TC levels (Fig.5-C, D)

How to Choose the Right GLP-1 for You Choosing the right GLP-1 medication can feel overwhelming, but here are some tips to make it easier: Consult with Your Doctor: Your healthcare provider can talk with you about your options and help you understand the best medication for you

Lee SH, Min SH, Cho YC, Han JH, Kim MN, Kim CR, et al