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GLP-1 is released from L cells in the distal ileum and colon, while GIP is secreted from K cells in the duodenum and jejunum and is responsible for most of the insulinotropic incretin effect [2]
The key difference is retatrutide's dysesthesia (20.9%) versus less than 1% with Wegovy or Mounjaro
Sci 361(6408) Cai Y, Hay M, Bishop VS (1996) Synaptic connections and interactions between area postrema and nucleus tractus solitarius
It also helps control and slow gastric emptying and blood sugars
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